How much of a loss is this?

Let's take away a few things such as:

• Life after death
• Psychic phenomenon
• Super intelligent aliens
• Non-corporeal beings
• Super intelligent humans
• Super intelligent computers
• Exotic mental disorders like multiple personality disorder
• Self help doctrines

The effect on religion and popular SF or F based fiction is obvious. Would this be minor or would this have a major effect on society and culture?